Betaine, naturally occurring in your body, is a versatile substance. It serves many functions. Eating foods high in betaine can support your body's natural production. You will get more betaine from beets than from synthetically manufactured betaine.
The majority of published research uses natural betaine, specifically BETAFIN. There is very little published work that uses synthetic betaine, either in the form of Betaine HCL, or Anhydrous. You can also search online to get more info about the comparing natural and synthetic betaine.
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Evidence research was conducted to understand what happens in cells when synthetic betaine HCL is used. Then, it was done in a heat stress model, which compared to all products.
These key findings may help explain why there might be a difference:
1. Synthetic betaine HCL in Vitro model.
This trial took place at the Danisco Animal Nutrition Research Center in Finland
It caused a concern response in gut cells, significantly (P<0.05), reducing transepithelial electrical resistance.
This causes weaker junctions between the gut cells, allowing antigens across the gut barrier to cause a harmful or costly inflammatory reaction.
2. Synthetic betaine anhydrous and HCl in vivo heat stress model in broilers.
Betafin natural betaine has a significantly (p<0.05), higher growth rate (8.8%) than the numerical, but insignificant, increase by synthetic anhydrous betaine (6.3%) or synthetic betaine HCL (6.4%).
Synthetic betaine is not as efficient as natural betaine. The synthetic anhydrous betaine and the synthetic HCl betaine appear to have no differences.